Intranasal administration of the chemotherapeutic perillyl alcohol results in selective delivery to the cerebrospinal fluid in rats

Perillyl alcohol (POH) has been extensively studied for the treatment of peripheral and primary brain tumors. The intranasal route of administration has been preferred for dosing POH in early-stage clinical trials associated with promising outcomes in primary brain cancer. However, it is unclear how...

Descripción completa

Detalles Bibliográficos
Autores principales: Nehra, Geetika, Andrews, Shannon, Rettig, Joan, Gould, Michael N., Haag, Jill D., Howard, Steven P., Thorne, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973779/
https://www.ncbi.nlm.nih.gov/pubmed/33737566
http://dx.doi.org/10.1038/s41598-021-85293-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973779/
https://www.ncbi.nlm.nih.gov/pubmed/33737566
http://dx.doi.org/10.1038/s41598-021-85293-4

Ejemplares similares