IDH1 gene mutation activates Smad signaling molecules to regulate the expression levels of cell cycle and biological rhythm genes in human glioma U87-MG cells

Isocitrate dehydrogenase1 (IDH1) mutation is the most important genetic change in glioma. The most common IDH1 mutation results in the amino acid substitution of arginine 132 (Arg/R132), which is located at the active site of the enzyme. IDH1 Arg132His (R132H) mutation can reduce the proliferative r...

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Detalles Bibliográficos
Autores principales: Gao, Yongying, Wu, Yanwei, Zhang, Ningmei, Yuan, Hongmei, Wang, Fei, Xu, Hui, Yu, Jiaxiang, Ma, Jie, Hou, Shaozhang, Cao, Xiangmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974315/
https://www.ncbi.nlm.nih.gov/pubmed/33760141
http://dx.doi.org/10.3892/mmr.2021.11993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974315/
https://www.ncbi.nlm.nih.gov/pubmed/33760141
http://dx.doi.org/10.3892/mmr.2021.11993

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