Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands

Once inside the cytoplasm of a cell, mRNA can be used to treat disease by upregulating the expression of any gene. Lipid nanoparticles (LNPs) can deliver mRNA to hepatocytes in humans, yet systemic non‐hepatocyte delivery at clinical doses remains difficult. We noted that LNPs have historically been...

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Detalles Bibliográficos
Autores principales: Gan, Zubao, Lokugamage, Melissa P., Hatit, Marine Z. C., Loughrey, David, Paunovska, Kalina, Sato, Manaka, Cristian, Ana, Dahlman, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974401/
https://www.ncbi.nlm.nih.gov/pubmed/33758781
http://dx.doi.org/10.1002/btm2.10161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974401/
https://www.ncbi.nlm.nih.gov/pubmed/33758781
http://dx.doi.org/10.1002/btm2.10161

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