Cargando…

Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF-κB signaling

Cigarette smoke (CS) exposure is a risk factor for dyslipidemia and atherosclerosis. Reduced expression of low-density lipoprotein receptor (LDLR) in hepatocytes may be one of the underlying mechanisms for these disorders. The aim of the present study was to investigate the molecular mechanism under...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Baitao, Wang, Xuebin, Zhang, Rui, Niu, Shuai, Rong, Zhihua, Ni, Leng, Di, Xiao, Han, Qin, Liu, Changwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974406/ https://www.ncbi.nlm.nih.gov/pubmed/33760160 http://dx.doi.org/10.3892/mmr.2021.11970

Ejemplares similares

Cigarette smoke exposure impairs lipid metabolism by decreasing low-density lipoprotein receptor expression in hepatocytes
por: Ma, Baitao, et al.
Publicado: (2020)

Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells
por: Zhao, Zhewei, et al.
Publicado: (2021)

Systematic review and meta-analysis of the prevalence of venous thromboembolic events in novel coronavirus disease-2019 patients
por: Zhang, Rui, et al.
Publicado: (2021)

Differential roles of Scavenger receptor class B type I: A protective molecule and a facilitator of atherosclerosis
por: Ma, Baitao, et al.
Publicado: (2020)

Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis
por: Zhang, Rui, et al.
Publicado: (2021)

COVID-19: Melatonin as a potential adjuvant treatment
por: Zhang, Rui, et al.
Publicado: (2020)

MCU-knockdown attenuates high glucose-induced inflammation through regulating MAPKs/NF-κB pathways and ROS production in HepG2 cells
por: Panahi, Ghodratollah, et al.
Publicado: (2018)

Impact of Soy β-Conglycinin Peptides on PCSK9 Protein Expression in HepG2 Cells
por: Macchi, Chiara, et al.
Publicado: (2021)

Allicin and Capsaicin Ameliorated Hypercholesterolemia by Upregulating LDLR and Downregulating PCSK9 Expression in HepG2 Cells
por: Nawaka, Nantiya, et al.
Publicado: (2022)

Induction of Apoptosis by Berberine in Hepatocellular Carcinoma HepG2 Cells via Downregulation of NF-κB
por: Li, Min, et al.
Publicado: (2017)

E-Cigarette Flavoring Chemicals Induce Cytotoxicity in HepG2 Cells
por: Rickard, Brittany P., et al.
Publicado: (2021)

Anti-Inflammatory Effect of Protopine through MAPK and NF-κB Signaling Regulation in HepG2 Cell
por: Kim, MinGyu, et al.
Publicado: (2022)

Surfactin-Induced Apoptosis Through ROS–ERS–Ca(2+)-ERK Pathways in HepG2 Cells
por: Wang, Chun-ling, et al.
Publicado: (2013)

Alpinetin inhibits breast cancer growth by ROS/NF‐κB/HIF‐1α axis
por: Zhang, Tao, et al.
Publicado: (2020)

Melatonin attenuates high glucose‑induced endothelial cell pyroptosis by activating the Nrf2 pathway to inhibit NLRP3 inflammasome activation
por: Wang, Xuebin, et al.
Publicado: (2023)

Lupin Peptides Modulate the Protein-Protein Interaction of PCSK9 with the Low Density Lipoprotein Receptor in HepG2 Cells
por: Lammi, Carmen, et al.
Publicado: (2016)

Inhibition of NF-κB transcriptional activation in HepG2 cells by diterpenoids from the soft coral Sinularia maxima
por: Thao, Nguyen Phuong, et al.
Publicado: (2013)

Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation
por: Liu, Xiaoning, et al.
Publicado: (2018)

Cigarette Smoke Extract Stimulates MMP-2 Production in Nasal Fibroblasts via ROS/PI3K, Akt, and NF-κB Signaling Pathways
por: Park, Joo-Hoo, et al.
Publicado: (2020)

Cigarette smoke-associated inflammation impairs bone remodeling through NFκB activation
por: Lu, Yi, et al.
Publicado: (2021)

17β-Estradiol Inhibits PCSK9-Mediated LDLR Degradation Through GPER/PLC Activation in HepG2 Cells
por: Fu, Wei, et al.
Publicado: (2020)

Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling
por: Rastrick, Joseph M. D., et al.
Publicado: (2013)

Curdlan sulphate modulates protein synthesis and enhances NF-κB and C/EBP binding activity in HepG2 cells
por: Guzdek, A., et al.
Publicado: (1997)

Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells
por: Chen, Hung-Chen, et al.
Publicado: (2016)

Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells
por: Masagalli, Jagadeesh Nagarajappa, et al.
Publicado: (2021)

Geniposide promotes autophagy to inhibit insulin resistance in HepG2 cells via P62/NF-κB/GLUT-4
por: Jiang, Hongwei, et al.
Publicado: (2017)

Benzophenones from Anemarrhena asphodeloides Bge. Exhibit Anticancer Activity in HepG2 Cells via the NF-κB Signaling Pathway
por: Wu, De-Ling, et al.
Publicado: (2019)

Correction: Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling
por: Rastrick, Joseph M. D., et al.
Publicado: (2013)

Germacrone induces caspase-3/GSDME activation and enhances ROS production, causing HepG2 pyroptosis
por: Sun, Xinfeng, et al.
Publicado: (2022)

Oleanolic Acid Attenuates Insulin Resistance via NF-κB to Regulate the IRS1-GLUT4 Pathway in HepG2 Cells
por: Li, Ming, et al.
Publicado: (2015)

Inhibition of TNF-α-Mediated NF-κB Transcriptional Activity by Dammarane-Type Ginsenosides from Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells
por: Cho, Kyoungwon, et al.
Publicado: (2014)

Resveratrol metabolites ameliorate insulin resistance in HepG2 hepatocytes by modulating IRS-1/AMPK
por: Teng, Wendi, et al.
Publicado: (2018)

Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways
por: Zhang, Chao, et al.
Publicado: (2016)

Curcumin and Andrographolide Co-Administration Safely Prevent Steatosis Induction and ROS Production in HepG2 Cell Line
por: Pipitone, Rosaria Maria, et al.
Publicado: (2023)

Involvement of NOX2-derived ROS in human hepatoma HepG2 cell death induced by Entamoeba histolytica
por: Lee, Young Ah, et al.
Publicado: (2023)

Inhibition of TNF-α-mediated NF-κB Transcriptional Activity in HepG2 Cells by Dammarane-type Saponins from Panax ginseng Leaves
por: Song, Seok Bean, et al.
Publicado: (2012)

Ginsenoside Rg1 Ameliorates Palmitic Acid-Induced Hepatic Steatosis and Inflammation in HepG2 Cells via the AMPK/NF-κB Pathway
por: Xiao, Qing, et al.
Publicado: (2019)

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo
por: Cykowiak, Marta, et al.
Publicado: (2021)

Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injury
por: YANG, GENHUAN, et al.
Publicado: (2015)

2,4,6-Trinitrotoluene Induces Apoptosis via ROS-Regulated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in HepG2 and Hep3B Cells
por: Liao, Hung-Yu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qkd4bajnnkapjkcm3sfevjf46i