Brucine inhibits proliferation of glioblastoma cells by targeting the G-quadruplexes in the c-Myb promoter

The proto-oncogene c-Myb plays an important role in cell proliferation, and its upregulation affects the development of glioblastomas. G-quadruplexes are secondary DNA or RNA structures that usually form in the promoter region of oncogenes, including c-Myb, and regulate the expression of these genes...

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Detalles Bibliográficos
Autores principales: Liu, Qiaochu, Wang, Qunhui, Lv, Chuanqi, Liu, Ziqiang, Gao, Haijun, Chen, Yong, Zhao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974541/
https://www.ncbi.nlm.nih.gov/pubmed/33753997
http://dx.doi.org/10.7150/jca.53689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974541/
https://www.ncbi.nlm.nih.gov/pubmed/33753997
http://dx.doi.org/10.7150/jca.53689

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