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miR-449a Repression Leads to Enhanced NOTCH Signaling in TMPRSS2:ERG Fusion Positive Prostate Cancer Cells

SIMPLE SUMMARY: The reason for the frequent presence of the TMPRSS2:ERG (T2E) gene fusion in prostate cancer (PCa) is not fully understood. We were interested in investigating epigenomic alterations associated with the T2E gene fusion in PCa cells. Making use of publicly available genome-wide data a...

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Detalles Bibliográficos
Autores principales: Bauer, Simone, Ratz, Leonie, Heckmann-Nötzel, Doreen, Kaczorowski, Adam, Hohenfellner, Markus, Kristiansen, Glen, Duensing, Stefan, Altevogt, Peter, Klauck, Sabine M., Sültmann, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975324/
https://www.ncbi.nlm.nih.gov/pubmed/33669024
http://dx.doi.org/10.3390/cancers13050964