The role of GLS1-mediated glutaminolysis/2-HG/H3K4me3 and GSH/ROS signals in Th17 responses counteracted by PPARγ agonists

Background: Peroxisome proliferator-activated receptor gamma (PPARγ) has the ability to counter Th17 responses, but the full mechanisms remain elusive. Herein, we aimed to elucidate this process in view of cellular metabolism, especially glutaminolysis. Methods: MTT, CCK-8, Annexin V-FITC/PI stainin...

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Detalles Bibliográficos
Autores principales: Miao, Yumeng, Zheng, Yun, Geng, Yanzhi, Yang, Ling, Cao, Na, Dai, Yue, Wei, Zhifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977454/
https://www.ncbi.nlm.nih.gov/pubmed/33754076
http://dx.doi.org/10.7150/thno.54803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977454/
https://www.ncbi.nlm.nih.gov/pubmed/33754076
http://dx.doi.org/10.7150/thno.54803

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