Balancing the stability and drug activation in adaptive nanoparticles potentiates chemotherapy in multidrug-resistant cancer

Rationale: Prodrug strategies that render the drug temporarily inactive through a cleavable linkage are able to modulate the physicochemical properties of drugs for adaptive nanoparticle (NP) formulation. Here we used cabazitaxel as a model compound to test the validity of our “balancing NP stabilit...

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Detalles Bibliográficos
Autores principales: Wan, Jianqin, Huang, Lingling, Cheng, Jiangting, Qi, Huangfu, Jin, Jiahui, Wang, Hangxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977460/
https://www.ncbi.nlm.nih.gov/pubmed/33754053
http://dx.doi.org/10.7150/thno.54066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977460/
https://www.ncbi.nlm.nih.gov/pubmed/33754053
http://dx.doi.org/10.7150/thno.54066

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