GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape

Immune escape mechanisms employed by neuroblastoma (NB) cells include secretion of immunosuppressive factors disrupting effective antitumor immunity. The use of cellular therapy to treat solid tumors needs to be implemented. Killing activity of anti-GD2 Chimeric Antigen Receptor (CAR) T or natural k...

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Detalles Bibliográficos
Autores principales: Caforio, Matteo, Sorino, Cristina, Caruana, Ignazio, Weber, Gerrit, Camera, Antonio, Cifaldi, Loredana, De Angelis, Biagio, Del Bufalo, Francesca, Vitale, Alessia, Goffredo, Bianca Maria, De Vito, Rita, Fruci, Doriana, Quintarelli, Concetta, Fanciulli, Maurizio, Locatelli, Franco, Folgiero, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978286/
https://www.ncbi.nlm.nih.gov/pubmed/33737337
http://dx.doi.org/10.1136/jitc-2020-001502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978286/
https://www.ncbi.nlm.nih.gov/pubmed/33737337
http://dx.doi.org/10.1136/jitc-2020-001502

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