Thyroid hormone plus dual-specificity phosphatase-5 siRNA increases the number of cardiac muscle cells and improves left ventricular contractile function in chronic doxorubicin-injured hearts

Rationale: Doxorubicin is a widely used anticancer drug. However, its major side effect, cardiotoxicity, results from cardiomyocyte loss that causes left ventricle (LV) wall thinning, chronic LV dysfunction and heart failure. Cardiomyocyte number expansion by thyroid hormone (T3) during preadolescen...

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Detalles Bibliográficos
Autores principales: Tan, Lin, Bogush, Nikolay, Naqvi, Emmen, Calvert, John W., Graham, Robert M., Taylor, W. Robert, Naqvi, Nawazish, Husain, Ahsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978295/
https://www.ncbi.nlm.nih.gov/pubmed/33754028
http://dx.doi.org/10.7150/thno.57456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978295/
https://www.ncbi.nlm.nih.gov/pubmed/33754028
http://dx.doi.org/10.7150/thno.57456

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