SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux

Rationale: Sirtuins are NAD(+)-dependent protein deacylases known to have protective effects against age-related diseases such as diabetes, cancer, and neurodegenerative disease. SIRT2 is the only primarily cytoplasmic isoform and its overall role in glucose homeostasis remains uncertain. Methods: S...

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Detalles Bibliográficos
Autores principales: Zhou, Feiye, Zhang, Linlin, Zhu, Kecheng, Bai, Mengyao, Zhang, Yuqing, Zhu, Qin, Wang, Shushu, Sheng, Chunxiang, Yuan, Miaomiao, Liu, Yun, Lu, Jieli, Shao, Li, Wang, Xiao, Zhou, Libin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978320/
https://www.ncbi.nlm.nih.gov/pubmed/33754030
http://dx.doi.org/10.7150/thno.55330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978320/
https://www.ncbi.nlm.nih.gov/pubmed/33754030
http://dx.doi.org/10.7150/thno.55330

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