Discovery of novel dual adenosine A(1)/A(2A) receptor antagonists using deep learning, pharmacophore modeling and molecular docking

Adenosine receptors (ARs) have been demonstrated to be potential therapeutic targets against Parkinson’s disease (PD). In the present study, we describe a multistage virtual screening approach that identifies dual adenosine A(1) and A(2A) receptor antagonists using deep learning, pharmacophore model...

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Detalles Bibliográficos
Autores principales: Wang, Mukuo, Hou, Shujing, Wei, Yu, Li, Dongmei, Lin, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978378/
https://www.ncbi.nlm.nih.gov/pubmed/33739970
http://dx.doi.org/10.1371/journal.pcbi.1008821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978378/
https://www.ncbi.nlm.nih.gov/pubmed/33739970
http://dx.doi.org/10.1371/journal.pcbi.1008821

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