Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation

Endothelial cyclooxygenase-1–derived prostanoids, including prostacyclin, have clear cardioprotective roles associated with their anti-thrombotic potential but have also been suggested to have paradoxical pathological activities within arteries. To date it has not been possible to test the importanc...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitchell, Jane A., Shala, Fisnik, Pires, Maria Elisa Lopes, Loy, Rachel Y., Ravendren, Andrew, Benson, Joshua, Urquhart, Paula, Nicolaou, Anna, Herschman, Harvey R., Kirkby, Nicholas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978428/
https://www.ncbi.nlm.nih.gov/pubmed/33741600
http://dx.doi.org/10.1126/sciadv.abf6054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978428/
https://www.ncbi.nlm.nih.gov/pubmed/33741600
http://dx.doi.org/10.1126/sciadv.abf6054

Ejemplares similares