HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner

Uncovering the mechanisms that underpin how tumor cells adapt to microenvironmental stress is essential to better understand cancer progression. The HACE1 (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase) gene is a tumor suppressor that inhibits the growth, invasive capacity, a...

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Detalles Bibliográficos
Autores principales: Turgu, Busra, Zhang, Fan, El-Naggar, Amal, Negri, Gian Luca, Kogler, Melanie, Tortola, Luigi, Johnson, Fraser, Ng, Tony, Li, Amy, Yapp, Donald, Lockwood, William, Martinez, Daniel, Maris, John M., Daugaard, Mads, Penninger, Josef M., Hughes, Christopher S., Sorensen, Poul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979542/
https://www.ncbi.nlm.nih.gov/pubmed/33603169
http://dx.doi.org/10.1038/s41388-021-01680-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979542/
https://www.ncbi.nlm.nih.gov/pubmed/33603169
http://dx.doi.org/10.1038/s41388-021-01680-1

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