Cargando…

HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner

Uncovering the mechanisms that underpin how tumor cells adapt to microenvironmental stress is essential to better understand cancer progression. The HACE1 (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase) gene is a tumor suppressor that inhibits the growth, invasive capacity, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Turgu, Busra, Zhang, Fan, El-Naggar, Amal, Negri, Gian Luca, Kogler, Melanie, Tortola, Luigi, Johnson, Fraser, Ng, Tony, Li, Amy, Yapp, Donald, Lockwood, William, Martinez, Daniel, Maris, John M., Daugaard, Mads, Penninger, Josef M., Hughes, Christopher S., Sorensen, Poul H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979542/ https://www.ncbi.nlm.nih.gov/pubmed/33603169 http://dx.doi.org/10.1038/s41388-021-01680-1

Ejemplares similares

HACE1 is a potential tumor suppressor in osteosarcoma
por: El-Naggar, Amal M, et al.
Publicado: (2019)

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes
por: Daugaard, Mads, et al.
Publicado: (2013)

Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation
por: Andrio, Emilie, et al.
Publicado: (2017)

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
por: Tortola, Luigi, et al.
Publicado: (2016)

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
por: Tortola, Luigi, et al.
Publicado: (2016)

Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division
por: Petracchini, Serena, et al.
Publicado: (2022)

Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction
por: Cetinbas, Naniye, et al.
Publicado: (2014)

HACE1, RAC1, and what else in the pathogenesis of SPPRS?
por: Deng, Han-Xiang
Publicado: (2019)

TNF-driven cell fate: till HACE do us part
por: Tortola, Luigi, et al.
Publicado: (2016)

Ubiquitylation of active Rac1 by the E3 Ubiquitin-Ligase HACE1
por: Mettouchi, Amel, et al.
Publicado: (2012)

HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress
por: Zhang, Liyong, et al.
Publicado: (2014)

Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression
por: Goka, E T, et al.
Publicado: (2015)

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination
por: Acosta, Maria I., et al.
Publicado: (2018)

HACE1 deficiency leads to structural and functional neurodevelopmental defects
por: Nagy, Vanja, et al.
Publicado: (2019)

The pro-tumoral function of HACE1
por: El-Hachem, Najla, et al.
Publicado: (2018)

HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells
por: Weidemann, Alexander, et al.
Publicado: (2013)

Stanniocalcin2, but Not Stanniocalcin1, Responds to Hypoxia in a HIF1-Dependent Manner in the Retina
por: Ail, Divya, et al.
Publicado: (2022)

The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction–dependent manner
por: Keller-Pinter, Aniko, et al.
Publicado: (2017)

The Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates Hif-1α and Glut-1 Expression and Glucose Uptake in the Brain
por: Hong, Jaewoo, et al.
Publicado: (2020)

HACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome
por: Hollstein, Ronja, et al.
Publicado: (2015)

The Enterohemorrhagic Escherichia coli Effector EspW Triggers Actin Remodeling in a Rac1-Dependent Manner
por: Sandu, Pamela, et al.
Publicado: (2017)

Hypoxic induction of vasculogenic mimicry in hepatocellular carcinoma: role of HIF-1 α, RhoA/ROCK and Rac1/PAK signaling
por: Zhang, Ji-Gang, et al.
Publicado: (2020)

Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner
por: Yamaguchi, Junna, et al.
Publicado: (2017)

PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
por: Zhou, Mi, et al.
Publicado: (2022)

A 1 bp deletion in HACE1 causes ataxia in Norwegian elkhound, black
por: Bellamy, Kim K. L., et al.
Publicado: (2022)

De novo and cell line models of human mammary cell transformation reveal an essential role for Yb-1 in multiple stages of human breast cancer
por: Lefort, Sylvain, et al.
Publicado: (2021)

Role of prolyl hydroxylase/HIF-1 signaling in vascular calcification
por: Negri, Armando Luis
Publicado: (2022)

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner
por: Bremm, Anja, et al.
Publicado: (2014)

Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner
por: Binó, Lucia, et al.
Publicado: (2017)

ContRac1ion-Mediated Glucose Uptake: A Central Role for Rac1
por: Lundell, Leonidas S., et al.
Publicado: (2013)

Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms
por: Marei, Hadir, et al.
Publicado: (2016)

Rac1 S71 Mediates the Interaction between Rac1 and 14-3-3 Proteins
por: Abdrabou, Abdalla, et al.
Publicado: (2019)

Mechanistic Differences of Activation of Rac1(P29S) and Rac1(A159V)
por: Senyuz, Simge, et al.
Publicado: (2021)

Hace mucho tiempo
por: Kennedy, Margaret, 1896-1967
Publicado: (1948)

Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma
por: Diskin, Sharon J, et al.
Publicado: (2012)

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
por: Zhou, Chun, et al.
Publicado: (2012)

PI3K and ERK-Induced Rac1 Activation Mediates Hypoxia-Induced HIF-1α Expression in MCF-7 Breast Cancer Cells
por: Du, Jun, et al.
Publicado: (2011)

HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1)
por: Cui, Feng, et al.
Publicado: (2012)

Nf2/Merlin Controls Spinal Cord Neural Progenitor Function in a Rac1/ErbB2-Dependent Manner
por: Garcia, Cynthia, et al.
Publicado: (2014)

A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association
por: Seyama, Rie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_770er83afi8g9vi312179n8bep