CRL4A(DTL) degrades DNA-PKcs to modulate NHEJ repair and induce genomic instability and subsequent malignant transformation

Genomic instability induced by DNA damage and improper DNA damage repair is one of the main causes of malignant transformation and tumorigenesis. DNA double strand breaks (DSBs) are the most detrimental form of DNA damage, and nonhomologous end-joining (NHEJ) mechanisms play dominant and priority ro...

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Detalles Bibliográficos
Autores principales: Feng, Maoxiao, Wang, Yunshan, Bi, Lei, Zhang, Pengju, Wang, Huaizhi, Zhao, Zhongxi, Mao, Jian-Hua, Wei, Guangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979543/
https://www.ncbi.nlm.nih.gov/pubmed/33627782
http://dx.doi.org/10.1038/s41388-021-01690-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979543/
https://www.ncbi.nlm.nih.gov/pubmed/33627782
http://dx.doi.org/10.1038/s41388-021-01690-z

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