Population pharmacokinetics and pharmacodynamics of a novel vascular adhesion protein-1 inhibitor using a multiple-target mediated drug disposition model

ASP8232 is a novel inhibitor of vascular adhesion protein-1 that was under evaluation for reducing residual albuminuria in patients with diabetic kidney disease. To characterize the pharmacokinetics (PK) of ASP8232 and its effect on vascular adhesion protein 1 (VAP-1) plasma activity and VAP-1 conce...

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Detalles Bibliográficos
Autores principales: Snelder, Nelleke, Hoefman, Sven, Garcia-Hernandez, Alberto, Onkels, Hartmut, Larsson, Tobias E., Bergmann, Kirsten R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979583/
https://www.ncbi.nlm.nih.gov/pubmed/32930923
http://dx.doi.org/10.1007/s10928-020-09717-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979583/
https://www.ncbi.nlm.nih.gov/pubmed/32930923
http://dx.doi.org/10.1007/s10928-020-09717-w

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