Mechanism-based modeling of the effect of a novel inhibitor of vascular adhesion protein-1 on albuminuria and renal function markers in patients with diabetic kidney disease

The vascular adhesion protein-1 (VAP-1) inhibitor ASP8232 reduces albuminuria in patients with type 2 diabetes and chronic kidney disease. A mechanism-based model was developed to quantify the effects of ASP8232 on renal markers from a placebo-controlled Phase 2 study in diabetic kidney disease with...

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Detalles Bibliográficos
Autores principales: Hoefman, Sven, Snelder, Nelleke, van Noort, Martijn, Garcia-Hernandez, Alberto, Onkels, Hartmut, Larsson, Tobias E., Bergmann, Kirsten R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979602/
https://www.ncbi.nlm.nih.gov/pubmed/32929612
http://dx.doi.org/10.1007/s10928-020-09716-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979602/
https://www.ncbi.nlm.nih.gov/pubmed/32929612
http://dx.doi.org/10.1007/s10928-020-09716-x

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