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In-peptide amino acid racemization via inter-residue oxazoline intermediates during acidic hydrolysis

Isopedopeptins are antibiotic cyclic lipodepsipeptides containing the subsequence L-Thr—L-2,3-diaminopropanoic acid—D-Phe—L-Val/L-3-hydroxyvaline. Acidic hydrolysis of isopedopeptins in D(2)O showed the D-Phe residues to racemize extensively in peptides with L-3-hydroxyvaline but not in peptides wit...

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Detalles Bibliográficos
Autores principales: Broberg, Anders, Nord, Christina, Levenfors, Jolanta J., Bjerketorp, Joakim, Guss, Bengt, Öberg, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979671/
https://www.ncbi.nlm.nih.gov/pubmed/33586040
http://dx.doi.org/10.1007/s00726-021-02951-7