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In-peptide amino acid racemization via inter-residue oxazoline intermediates during acidic hydrolysis
Isopedopeptins are antibiotic cyclic lipodepsipeptides containing the subsequence L-Thr—L-2,3-diaminopropanoic acid—D-Phe—L-Val/L-3-hydroxyvaline. Acidic hydrolysis of isopedopeptins in D(2)O showed the D-Phe residues to racemize extensively in peptides with L-3-hydroxyvaline but not in peptides wit...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Vienna
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979671/ https://www.ncbi.nlm.nih.gov/pubmed/33586040 http://dx.doi.org/10.1007/s00726-021-02951-7 |