Cargando…
Structural and functional insights into esterase-mediated macrolide resistance
Macrolides are a class of antibiotics widely used in both medicine and agriculture. Unsurprisingly, as a consequence of their exensive usage a plethora of resistance mechanisms have been encountered in pathogenic bacteria. One of these resistance mechanisms entails the enzymatic cleavage of the macr...
Autores principales: | Zieliński, Michał, Park, Jaeok, Sleno, Barry, Berghuis, Albert M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979712/ https://www.ncbi.nlm.nih.gov/pubmed/33741980 http://dx.doi.org/10.1038/s41467-021-22016-3 |
Ejemplares similares
-
Look and Outlook on Enzyme-Mediated Macrolide Resistance
por: Golkar, Tolou, et al.
Publicado: (2018) -
Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
por: Park, Jaeok, et al.
Publicado: (2017) -
Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure
por: Park, Jaeok, et al.
Publicado: (2012) -
Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate
por: Park, Jaeok, et al.
Publicado: (2014) -
Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective
por: Park, Jaeok, et al.
Publicado: (2021)