An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing

Extensive testing is essential to break the transmission of SARS-CoV-2, which causes the ongoing COVID-19 pandemic. Here, we present a CRISPR-based diagnostic assay that is robust to viral genome mutations and temperature, produces results fast, can be applied directly on nasopharyngeal (NP) specime...

Descripción completa

Detalles Bibliográficos
Autores principales: Ooi, Kean Hean, Liu, Mengying Mandy, Tay, Jie Wen Douglas, Teo, Seok Yee, Kaewsapsak, Pornchai, Jin, Shengyang, Lee, Chun Kiat, Hou, Jingwen, Maurer-Stroh, Sebastian, Lin, Weisi, Yan, Benedict, Yan, Gabriel, Gao, Yong-Gui, Tan, Meng How
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979722/
https://www.ncbi.nlm.nih.gov/pubmed/33741959
http://dx.doi.org/10.1038/s41467-021-21996-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979722/
https://www.ncbi.nlm.nih.gov/pubmed/33741959
http://dx.doi.org/10.1038/s41467-021-21996-6

Ejemplares similares