Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis

ATM and ATR are conserved regulators of the DNA damage response linked to cancer. Comprehensive DNA sequencing efforts identified ~4,000 cancer-associated mutations in ATM/ATR; however, their cancer implications remain largely unknown. To gain insights, we identify functionally important conserved r...

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Detalles Bibliográficos
Autores principales: Waskiewicz, Erik, Vasiliou, Michalis, Corcoles-Saez, Isaac, Cha, Rita S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979806/
https://www.ncbi.nlm.nih.gov/pubmed/33742106
http://dx.doi.org/10.1038/s42003-021-01884-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979806/
https://www.ncbi.nlm.nih.gov/pubmed/33742106
http://dx.doi.org/10.1038/s42003-021-01884-x

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