Cargando…

Identification of disease treatment mechanisms through the multiscale interactome

Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins. How drugs restore these functions, however, is often unknown as a drug’s therapeutic effects are not limited to the proteins that the drug directly targets. Here, we develop t...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruiz, Camilo, Zitnik, Marinka, Leskovec, Jure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979814/
https://www.ncbi.nlm.nih.gov/pubmed/33741907
http://dx.doi.org/10.1038/s41467-021-21770-8