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Identification of disease treatment mechanisms through the multiscale interactome
Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins. How drugs restore these functions, however, is often unknown as a drug’s therapeutic effects are not limited to the proteins that the drug directly targets. Here, we develop t...
Autores principales: | Ruiz, Camilo, Zitnik, Marinka, Leskovec, Jure |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979814/ https://www.ncbi.nlm.nih.gov/pubmed/33741907 http://dx.doi.org/10.1038/s41467-021-21770-8 |
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