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R-loop resolution promotes co-transcriptional chromatin silencing

RNA-mediated chromatin silencing is central to genome regulation in many organisms. However, how nascent non-coding transcripts regulate chromatin is poorly understood. Here, through analysis of Arabidopsis FLC, we show that resolution of a nascent-transcript-induced R-loop promotes chromatin silenc...

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Detalles Bibliográficos
Autores principales: Xu, Congyao, Wu, Zhe, Duan, Hong-Chao, Fang, Xiaofeng, Jia, Guifang, Dean, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979926/
https://www.ncbi.nlm.nih.gov/pubmed/33741984
http://dx.doi.org/10.1038/s41467-021-22083-6