Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis

Microsomal glutathione S-transferase 2 (MGST2) produces leukotriene C(4), key for intracrine signaling of endoplasmic reticulum (ER) stress, oxidative DNA damage and cell death. MGST2 trimer restricts catalysis to only one out of three active sites at a time, but the molecular basis is unknown. Here...

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Detalles Bibliográficos
Autores principales: Thulasingam, Madhuranayaki, Orellana, Laura, Nji, Emmanuel, Ahmad, Shabbir, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979937/
https://www.ncbi.nlm.nih.gov/pubmed/33741927
http://dx.doi.org/10.1038/s41467-021-21924-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979937/
https://www.ncbi.nlm.nih.gov/pubmed/33741927
http://dx.doi.org/10.1038/s41467-021-21924-8

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