Restoration of mGluR6 Localization Following AAV-Mediated Delivery in a Mouse Model of Congenital Stationary Night Blindness

PURPOSE: Complete congenital stationary night blindness (cCSNB) is an incurable inherited retinal disorder characterized by an ON-bipolar cell (ON-BC) defect. GRM6 mutations are the third most prevalent cause of cCSNB. The Grm6(−)(/)(−) mouse model mimics the human phenotype, showing no b-wave in th...

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Detalles Bibliográficos
Autores principales: Varin, Juliette, Bouzidi, Nassima, Dias, Miguel Miranda De Sousa, Pugliese, Thomas, Michiels, Christelle, Robert, Camille, Desrosiers, Melissa, Sahel, José-Alain, Audo, Isabelle, Dalkara, Deniz, Zeitz, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Visual Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980044/
https://www.ncbi.nlm.nih.gov/pubmed/33729473
http://dx.doi.org/10.1167/iovs.62.3.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980044/
https://www.ncbi.nlm.nih.gov/pubmed/33729473
http://dx.doi.org/10.1167/iovs.62.3.24

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