Cargando…

Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis

We and others previously demonstrated that a type 1 diabetes genetic risk score (GRS) improves the ability to predict disease progression and onset in at-risk subjects with islet autoantibodies. Here, we hypothesized that GRS and islet autoantibodies, combined with age at onset and disease duration,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Williams, MacKenzie D., Bacher, Rhonda, Perry, Daniel J., Grace, C. Ramsey, McGrail, Kieran M., Posgai, Amanda L., Muir, Andrew, Chamala, Srikar, Haller, Michael J., Schatz, Desmond A., Brusko, Todd M., Atkinson, Mark A., Wasserfall, Clive H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2021
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980194/ https://www.ncbi.nlm.nih.gov/pubmed/33419759 http://dx.doi.org/10.2337/db20-0937

Ejemplares similares

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes
por: Xue, Song, et al.
Publicado: (2015)

Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes
por: Mathews, Clayton E., et al.
Publicado: (2015)

Serum Trypsinogen Levels in Type 1 Diabetes
por: Li, Xia, et al.
Publicado: (2017)

339 A serum exocrine enzyme as a biomarker of response to immunotherapy in type 1 diabetes.
por: Bruggeman, Brittany S, et al.
Publicado: (2022)

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes
por: Campbell-Thompson, Martha, et al.
Publicado: (2016)

Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes
por: Haller, Michael J., et al.
Publicado: (2009)

Reduced Serum Vitamin D–Binding Protein Levels Are Associated With Type 1 Diabetes
por: Blanton, Dustin, et al.
Publicado: (2011)

Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling
por: Perry, Daniel J., et al.
Publicado: (2018)

Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide
por: Haller, Michael J., et al.
Publicado: (2011)

A genomic data archive from the Network for Pancreatic Organ donors with Diabetes
por: Perry, Daniel J., et al.
Publicado: (2023)

Human immune phenotyping reveals accelerated aging in type 1 diabetes
por: Shapiro, Melanie R., et al.
Publicado: (2023)

Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies
por: Serreze, David V., et al.
Publicado: (2011)

Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice
por: Posgai, Amanda L., et al.
Publicado: (2017)

Influence of Membrane CD25 Stability on T Lymphocyte Activity: Implications for Immunoregulation
por: Brusko, Todd M., et al.
Publicado: (2009)

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice
por: Gill, Ronald G., et al.
Publicado: (2016)

Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses
por: Brusko, Maigan A., et al.
Publicado: (2020)

Vitamin D Levels in Subjects With and Without Type 1 Diabetes Residing in a Solar Rich Environment
por: Bierschenk, Lindsey, et al.
Publicado: (2009)

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability
por: Thirawatananond, Puchong, et al.
Publicado: (2023)

Nardilysin-Dependent Proteolysis of Cell-Associated VTCN1 (B7-H4) Marks Type 1 Diabetes Development
por: Radichev, Ilian A., et al.
Publicado: (2014)

The utility of phospholipase A2 receptor autoantibody in membranous nephropathy after kidney transplantation
por: Xipell, Marc, et al.
Publicado: (2018)

Distinguishing Persistent Insulin Autoantibodies With Differential Risk: Nonradioactive Bivalent Proinsulin/Insulin Autoantibody Assay
por: Yu, Liping, et al.
Publicado: (2012)

Type 1 Interferons Potentiate Human CD8(+) T-Cell Cytotoxicity Through a STAT4- and Granzyme B–Dependent Pathway
por: Newby, Brittney N., et al.
Publicado: (2017)

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes
por: Haller, Michael J., et al.
Publicado: (2016)

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes
por: Putnam, Amy L., et al.
Publicado: (2009)

Interleukin-10(+) Regulatory B Cells Arise Within Antigen-Experienced CD40(+) B Cells to Maintain Tolerance to Islet Autoantigens
por: Kleffel, Sonja, et al.
Publicado: (2015)

Asbestos exposure and autoantibody titers
por: Lee, Eunsoo, et al.
Publicado: (2020)

Central Role for Interleukin-2 in Type 1 Diabetes
por: Hulme, Maigan A., et al.
Publicado: (2012)

Zinc transporter 8 autoantibody testing requires age-related cut-offs
por: Grace, Sian Louise, et al.
Publicado: (2021)

Increased Complement Activation in Human Type 1 Diabetes Pancreata
por: Rowe, Patrick, et al.
Publicado: (2013)

Successful Kidney Transplantation After Stepwise Desensitization Using Rituximab and Bortezomib in a Highly HLA-Sensitized and ABO Incompatible High Titer Patient
por: Inui, Masashi, et al.
Publicado: (2016)

Low Titers of Antidonor ABO Antibodies After ABO-Incompatible Living Donor Liver Transplantation: A Long-Term Follow-Up Study
por: Ueda, Daisuke, et al.
Publicado: (2018)

Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals With Presymptomatic Type 1 Diabetes
por: Kwon, Bum Chul, et al.
Publicado: (2022)

Conditioning intensity and probability of live birth after blood or marrow transplantation, a BMTSS report
por: Balas, Nora, et al.
Publicado: (2022)

A Safe Anti-A2 Titer for a Successful A2 Incompatible Kidney Transplantation: A Single-center Experience and Review of the Literature
por: Azzi, Yorg, et al.
Publicado: (2021)

Erratum: Asbestos exposure and autoantibody titers
por: Lee, Eunsoo, et al.
Publicado: (2021)

Biomaterials‐based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents
por: Marshall, Gregory P., et al.
Publicado: (2022)

Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes: A Twin and Population Study
por: Beyan, Huriya, et al.
Publicado: (2012)

Preexisting Autoantibodies Predict Efficacy of Oral Insulin to Cure Autoimmune Diabetes in Combination With Anti-CD3
por: Mamchak, Alusha A., et al.
Publicado: (2012)

Evaluation for type 1 diabetes associated autoantibodies in diabetic and non-diabetic Australian terriers and Samoyeds
por: O’Kell, Allison L., et al.
Publicado: (2020)

Exocrine and Endocrine Inflammation Increases Cellular Replication in the Pancreatic Duct Compartment in Type 1 Diabetes
por: Kulkarni, Shweta, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qi4qkfo5j3o9sb2n8kabj10qfd