Synthetic mRNA‐based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease‐induced pluripotent stem cells

Gaucher disease, the most prevalent metabolic storage disorder, is caused by mutations in the glucocerebrosidase gene GBA1, which lead to the accumulation of glucosylceramide (GlcCer) in affected cells. Gaucher disease type 1 (GD1), although defined as a nonneuronopathic subtype, is accompanied by a...

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Detalles Bibliográficos
Autores principales: Akiyama, Tomohiko, Sato, Saeko, Ko, Shigeru B. H., Sano, Osamu, Sato, Sho, Saito, Masayo, Nagai, Hiroaki, Ko, Minoru S. H., Iwata, Hidehisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Pluripotent Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980209/
https://www.ncbi.nlm.nih.gov/pubmed/33342090
http://dx.doi.org/10.1002/sctm.20-0302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980209/
https://www.ncbi.nlm.nih.gov/pubmed/33342090
http://dx.doi.org/10.1002/sctm.20-0302

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