Disruption of neonatal Purkinje cell function underlies injury-related learning deficits

It is hypothesized that perinatal cerebellar injury leads to long-term functional deficits due to circuit dysmaturation. Using a novel integration of GCaMP6f fiber photometry with automated measurement of cerebellar behavior using the ErasmusLadder, we causally link cerebellar injury to altered Purk...

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Detalles Bibliográficos
Autores principales: Sathyanesan, Aaron, Kratimenos, Panagiotis, Gallo, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980280/
https://www.ncbi.nlm.nih.gov/pubmed/33688045
http://dx.doi.org/10.1073/pnas.2017876118
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author Sathyanesan, Aaron
Kratimenos, Panagiotis
Gallo, Vittorio
author_facet Sathyanesan, Aaron
Kratimenos, Panagiotis
Gallo, Vittorio
author_sort Sathyanesan, Aaron
collection PubMed
description It is hypothesized that perinatal cerebellar injury leads to long-term functional deficits due to circuit dysmaturation. Using a novel integration of GCaMP6f fiber photometry with automated measurement of cerebellar behavior using the ErasmusLadder, we causally link cerebellar injury to altered Purkinje cell responses during maladaptive behavior. Chemogenetic inhibition of neonatal Purkinje cells is sufficient to phenocopy the effects of perinatal cerebellar injury. Our results uncover a direct link between perinatal cerebellar injury and activity-dependent maturation of cerebellar cortex.
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spelling pubmed-79802802021-03-26 Disruption of neonatal Purkinje cell function underlies injury-related learning deficits Sathyanesan, Aaron Kratimenos, Panagiotis Gallo, Vittorio Proc Natl Acad Sci U S A Biological Sciences It is hypothesized that perinatal cerebellar injury leads to long-term functional deficits due to circuit dysmaturation. Using a novel integration of GCaMP6f fiber photometry with automated measurement of cerebellar behavior using the ErasmusLadder, we causally link cerebellar injury to altered Purkinje cell responses during maladaptive behavior. Chemogenetic inhibition of neonatal Purkinje cells is sufficient to phenocopy the effects of perinatal cerebellar injury. Our results uncover a direct link between perinatal cerebellar injury and activity-dependent maturation of cerebellar cortex. National Academy of Sciences 2021-03-16 2021-03-09 /pmc/articles/PMC7980280/ /pubmed/33688045 http://dx.doi.org/10.1073/pnas.2017876118 Text en Copyright © 2021 the Author(s). Published by PNAS. http://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biological Sciences
Sathyanesan, Aaron
Kratimenos, Panagiotis
Gallo, Vittorio
Disruption of neonatal Purkinje cell function underlies injury-related learning deficits
title Disruption of neonatal Purkinje cell function underlies injury-related learning deficits
title_full Disruption of neonatal Purkinje cell function underlies injury-related learning deficits
title_fullStr Disruption of neonatal Purkinje cell function underlies injury-related learning deficits
title_full_unstemmed Disruption of neonatal Purkinje cell function underlies injury-related learning deficits
title_short Disruption of neonatal Purkinje cell function underlies injury-related learning deficits
title_sort disruption of neonatal purkinje cell function underlies injury-related learning deficits
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980280/
https://www.ncbi.nlm.nih.gov/pubmed/33688045
http://dx.doi.org/10.1073/pnas.2017876118
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