Cargando…

Neurodegenerative phosphoprotein signaling landscape in models of SCA3

Spinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disorder resulting from an aberrant expansion of a polyglutamine stretch in the ataxin-3 protein and subsequent neuronal death. The underlying intracellular signaling pathways are currently unknown. We applied the Reverse-phase Protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sowa, Anna S., Popova, Taissia G., Harmuth, Tina, Weber, Jonasz J., Pereira Sena, Priscila, Schmidt, Jana, Hübener-Schmid, Jeannette, Schmidt, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980345/ https://www.ncbi.nlm.nih.gov/pubmed/33741019 http://dx.doi.org/10.1186/s13041-020-00723-0

Ejemplares similares

Mitochondrial Dysfunction in Spinocerebellar Ataxia Type 3 Is Linked to VDAC1 Deubiquitination
por: Harmuth, Tina, et al.
Publicado: (2022)

From Pathways to Targets: Understanding the Mechanisms behind Polyglutamine Disease
por: Weber, Jonasz Jeremiasz, et al.
Publicado: (2014)

KPNB1 modulates the Machado–Joseph disease protein ataxin-3 through activation of the mitochondrial protease CLPP
por: Abeditashi, Mahkameh, et al.
Publicado: (2022)

Ataxin-3, The Spinocerebellar Ataxia Type 3 Neurodegenerative Disorder Protein, Affects Mast Cell Functions
por: Sowa, Anna S., et al.
Publicado: (2022)

Killing Two Angry Birds with One Stone: Autophagy Activation by Inhibiting Calpains in Neurodegenerative Diseases and Beyond
por: Weber, Jonasz Jeremiasz, et al.
Publicado: (2019)

A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes
por: Haas, Eva, et al.
Publicado: (2021)

Allele-specific targeting of mutant ataxin-3 by antisense oligonucleotides in SCA3-iPSC-derived neurons
por: Hauser, Stefan, et al.
Publicado: (2021)

Mitochondrial Morphology, Function and Homeostasis Are Impaired by Expression of an N-terminal Calpain Cleavage Fragment of Ataxin-3
por: Harmuth, Tina, et al.
Publicado: (2018)

Cerebellar Soluble Mutant Ataxin-3 Level Decreases during Disease Progression in Spinocerebellar Ataxia Type 3 Mice
por: Nguyen, Huu Phuc, et al.
Publicado: (2013)

Differential Temporal Dynamics of Axial and Appendicular Ataxia in SCA3
por: Maas, Roderick P.P.W.M., et al.
Publicado: (2022)

The frequency of non-motor symptoms in SCA3 and their association with disease severity and lifestyle factors
por: Hengel, Holger, et al.
Publicado: (2022)

Frequency of SCA8, SCA10, SCA12, SCA36, FXTAS and C9orf72 repeat expansions in SCA patients negative for the most common SCA subtypes
por: Aydin, Gülsah, et al.
Publicado: (2018)

Implications of specific lysine residues within ataxin-3 for the molecular pathogenesis of Machado-Joseph disease
por: Pereira Sena, Priscila, et al.
Publicado: (2023)

Analysis of SCA8, SCA10, SCA12, SCA17 and SCA19 in patients with unknown spinocerebellar ataxia: a Thai multicentre study
por: Choubtum, Lulin, et al.
Publicado: (2015)

PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study
por: Gonsior, Kathrin, et al.
Publicado: (2020)

Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse
por: Wiatr, Kalina, et al.
Publicado: (2019)

Tuscany SCA in action
por: Laws, Simon
Publicado: (2011)

Medicago PhosphoProtein Database: a repository for Medicago truncatula phosphoprotein data
por: Rose, Christopher M., et al.
Publicado: (2012)

Simplified Model of PKCγ Signaling Dysregulation and Cytosol-to-Membrane Translocation Kinetics During Neurodegenerative Spinocerebellar Ataxia Type 14 (SCA14)
por: Aslam, Naveed, et al.
Publicado: (2020)

Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications
por: Candelise, Niccolò, et al.
Publicado: (2021)

The Nucleoprotein and Phosphoprotein of Measles Virus
por: Guseva, Serafima, et al.
Publicado: (2019)

On the identification of potential novel therapeutic targets for spinocerebellar ataxia type 1 (SCA1) neurodegenerative disease using EvoPPI3
por: Sousa, André, et al.
Publicado: (2023)

RhoA Signaling in Neurodegenerative Diseases
por: Schmidt, Sissel Ida, et al.
Publicado: (2022)

Klotho protein in neurodegenerative disorders
por: Torbus-Paluszczak, Magdalena, et al.
Publicado: (2018)

Radiation Qualification of the SCA Controller Preselection
por: Gingrich, D M, et al.
Publicado: (2003)

Understanding SCA (Service Component Architecture)
por: Marino, Jim, et al.
Publicado: (2009)

Understanding SCA (Service Component Architecture)
por: Marino, Jim, et al.
Publicado: (2010)

COVID-19 et SCA ST+
por: Hakim, R., et al.
Publicado: (2020)

MR Imaging of SCA3/MJD
por: Wan, Na, et al.
Publicado: (2020)

Anthrax infection inhibits the AKT signaling involved in the E-cadherin-mediated adhesion of lung epithelial cells
por: Popova, Taissia, et al.
Publicado: (2009)

Calpains as novel players in the molecular pathogenesis of spinocerebellar ataxia type 17
por: Weber, Jonasz Jeremiasz, et al.
Publicado: (2022)

Altered dynamics of scaRNA2 and scaRNA9 in response to stress correlates with disrupted nuclear organization
por: Logan, Madelyn K., et al.
Publicado: (2018)

Phosphoprotein analysis: from proteins to proteomes
por: Delom, Frédéric, et al.
Publicado: (2006)

Molecular Evolution of Phosphoprotein Phosphatases in Drosophila
por: Miskei, Márton, et al.
Publicado: (2011)

Golgi phosphoprotein 2 in physiology and in diseases
por: Kim, Ha-Jeong, et al.
Publicado: (2012)

Designed Phosphoprotein Recognition in Escherichia coli
por: Sawyer, Nicholas, et al.
Publicado: (2014)

Pyrophosphorylation via selective phosphoprotein derivatization
por: Marmelstein, Alan M., et al.
Publicado: (2018)

Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
por: Hill, Steven M., et al.
Publicado: (2017)

Investigation of Lipid Profile and Clinical Manifestations in SCA Children
por: da Guarda, Caroline Conceição, et al.
Publicado: (2020)

Quantitative iTRAQ-based proteomic analysis of phosphoproteins and ABA-regulated phosphoproteins in maize leaves under osmotic stress
por: Hu, Xiuli, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_pfr4mla1noqvliaaa2c6j1p85j