Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans

Protein aggregation is associated with a wide range of degenerative human diseases with devastating consequences, as exemplified by Alzheimer’s, Parkinson’s, and Huntington’s diseases. In vitro kinetic studies have provided a mechanistic understanding of the aggregation process at the molecular leve...

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Detalles Bibliográficos
Autores principales: Sinnige, Tessa, Meisl, Georg, Michaels, Thomas C. T., Vendruscolo, Michele, Knowles, Tuomas P. J., Morimoto, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980373/
https://www.ncbi.nlm.nih.gov/pubmed/33836595
http://dx.doi.org/10.1073/pnas.2021888118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980373/
https://www.ncbi.nlm.nih.gov/pubmed/33836595
http://dx.doi.org/10.1073/pnas.2021888118

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