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Protein sequence design by conformational landscape optimization

The protein design problem is to identify an amino acid sequence that folds to a desired structure. Given Anfinsen’s thermodynamic hypothesis of folding, this can be recast as finding an amino acid sequence for which the desired structure is the lowest energy state. As this calculation involves not...

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Detalles Bibliográficos
Autores principales: Norn, Christoffer, Wicky, Basile I. M., Juergens, David, Liu, Sirui, Kim, David, Tischer, Doug, Koepnick, Brian, Anishchenko, Ivan, Baker, David, Ovchinnikov, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980421/
https://www.ncbi.nlm.nih.gov/pubmed/33712545
http://dx.doi.org/10.1073/pnas.2017228118