CD47 blockade reduces the pathologic features of experimental cerebral malaria and promotes survival of hosts with Plasmodium infection

CD47 is an antiphagocytic “don’t eat me” signal that inhibits programmed cell removal of self. As red blood cells (RBCs) age they lose CD47 expression and become susceptible to programmed cell removal by macrophages. CD47(−/−) mice infected with Plasmodium yoelii, which exhibits an age-based prefere...

Descripción completa

Detalles Bibliográficos
Autores principales: Torrez Dulgeroff, Laughing Bear, Oakley, Miranda S., Tal, Michal C., Yiu, Ying Ying, He, Joy Q., Shoham, Maia, Majam, Victoria, Okoth, Winter A., Malla, Pallavi, Kumar, Sanjai, Weissman, Irving L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980459/
https://www.ncbi.nlm.nih.gov/pubmed/33836556
http://dx.doi.org/10.1073/pnas.1907653118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980459/
https://www.ncbi.nlm.nih.gov/pubmed/33836556
http://dx.doi.org/10.1073/pnas.1907653118

Ejemplares similares