The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic

DNA gyrase, a type II topoisomerase, introduces negative supercoils into DNA using ATP hydrolysis. The highly effective gyrase-targeted drugs, fluoroquinolones (FQs), interrupt gyrase by stabilizing a DNA-cleavage complex, a transient intermediate in the supercoiling cycle, leading to double-strande...

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Detalles Bibliográficos
Autores principales: Feng, Lipeng, Mundy, Julia E. A., Stevenson, Clare E. M., Mitchenall, Lesley A., Lawson, David M., Mi, Kaixia, Maxwell, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980463/
https://www.ncbi.nlm.nih.gov/pubmed/33836580
http://dx.doi.org/10.1073/pnas.2016705118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980463/
https://www.ncbi.nlm.nih.gov/pubmed/33836580
http://dx.doi.org/10.1073/pnas.2016705118

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