Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as major upstream regulators of CD4(+) T cells from visceral leishmaniasis (VL) patients. Furthermor...

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Detalles Bibliográficos
Autores principales: Kumar, Rajiv, Bunn, Patrick T., Singh, Siddharth Sankar, Ng, Susanna S., de Oca, Marcela Montes, De Labastida Rivera, Fabian, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J., Edwards, Chelsea L., Frame, Teija C.M., Sheel, Meru, Austin, Rebecca J., Lane, Steven W., Bald, Tobias, Smyth, Mark J., Hill, Geoffrey.R., Best, Shannon E., Haque, Ashraful, Corvino, Dillon, Waddell, Nic, Koufariotis, Lambross, Mukhopadhay, Pamela, Rai, Madhukar, Chakravarty, Jaya, Singh, Om Prakash, Sacks, David, Nylen, Susanne, Uzonna, Jude, Sundar, Shyam, Engwerda, Christian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981274/
https://www.ncbi.nlm.nih.gov/pubmed/32101732
http://dx.doi.org/10.1016/j.celrep.2020.01.099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981274/
https://www.ncbi.nlm.nih.gov/pubmed/32101732
http://dx.doi.org/10.1016/j.celrep.2020.01.099

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