NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling

This is the first report of a NACC2‐NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profilin...

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Autores principales: Britton, Heidi M., Levine, Adrian B., Shen, Yaoqing, Mungall, Karen, Serrano, Jonathan, Snuderl, Matija, Pleasance, Erin, Jones, Steven J. M., Laskin, Janessa, Marra, Marco A., Rassekh, Shahrad R., Deyell, Rebecca, Yip, Stephen, Cheng, Sylvia, Dunham, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981675/
https://www.ncbi.nlm.nih.gov/pubmed/33768871
http://dx.doi.org/10.1002/ccr3.3804
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author Britton, Heidi M.
Levine, Adrian B.
Shen, Yaoqing
Mungall, Karen
Serrano, Jonathan
Snuderl, Matija
Pleasance, Erin
Jones, Steven J. M.
Laskin, Janessa
Marra, Marco A.
Rassekh, Shahrad R.
Deyell, Rebecca
Yip, Stephen
Cheng, Sylvia
Dunham, Chris
author_facet Britton, Heidi M.
Levine, Adrian B.
Shen, Yaoqing
Mungall, Karen
Serrano, Jonathan
Snuderl, Matija
Pleasance, Erin
Jones, Steven J. M.
Laskin, Janessa
Marra, Marco A.
Rassekh, Shahrad R.
Deyell, Rebecca
Yip, Stephen
Cheng, Sylvia
Dunham, Chris
author_sort Britton, Heidi M.
collection PubMed
description This is the first report of a NACC2‐NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profiling in cancer care.
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spelling pubmed-79816752021-03-24 NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling Britton, Heidi M. Levine, Adrian B. Shen, Yaoqing Mungall, Karen Serrano, Jonathan Snuderl, Matija Pleasance, Erin Jones, Steven J. M. Laskin, Janessa Marra, Marco A. Rassekh, Shahrad R. Deyell, Rebecca Yip, Stephen Cheng, Sylvia Dunham, Chris Clin Case Rep Case Reports This is the first report of a NACC2‐NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profiling in cancer care. John Wiley and Sons Inc. 2021-02-10 /pmc/articles/PMC7981675/ /pubmed/33768871 http://dx.doi.org/10.1002/ccr3.3804 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Britton, Heidi M.
Levine, Adrian B.
Shen, Yaoqing
Mungall, Karen
Serrano, Jonathan
Snuderl, Matija
Pleasance, Erin
Jones, Steven J. M.
Laskin, Janessa
Marra, Marco A.
Rassekh, Shahrad R.
Deyell, Rebecca
Yip, Stephen
Cheng, Sylvia
Dunham, Chris
NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling
title NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling
title_full NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling
title_fullStr NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling
title_full_unstemmed NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling
title_short NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling
title_sort ntrk2 fusion driven pediatric glioblastoma: identification of oncogenic drivers via integrative genome and transcriptome profiling
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981675/
https://www.ncbi.nlm.nih.gov/pubmed/33768871
http://dx.doi.org/10.1002/ccr3.3804
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