TOX as a potential target for immunotherapy in lymphocytic malignancies

TOX (thymocyte selection-associated HMG BOX) is a member of a family of transcriptional factors that contain the highly conserved high mobility group box (HMG-box) region. Increasing studies have shown that TOX is involved in maintaining tumors and promoting T cell exhaustion. In this review, we sum...

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Autores principales: Liang, Chaofeng, Huang, Shuxin, Zhao, Yujie, Chen, Shaohua, Li, Yangqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981945/
https://www.ncbi.nlm.nih.gov/pubmed/33743809
http://dx.doi.org/10.1186/s40364-021-00275-y
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author Liang, Chaofeng
Huang, Shuxin
Zhao, Yujie
Chen, Shaohua
Li, Yangqiu
author_facet Liang, Chaofeng
Huang, Shuxin
Zhao, Yujie
Chen, Shaohua
Li, Yangqiu
author_sort Liang, Chaofeng
collection PubMed
description TOX (thymocyte selection-associated HMG BOX) is a member of a family of transcriptional factors that contain the highly conserved high mobility group box (HMG-box) region. Increasing studies have shown that TOX is involved in maintaining tumors and promoting T cell exhaustion. In this review, we summarized the biological functions of TOX and its contribution as related to lymphocytic malignancies. We also discussed the potential role of TOX as an immune biomarker and target in immunotherapy for hematological malignancies.
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spelling pubmed-79819452021-03-22 TOX as a potential target for immunotherapy in lymphocytic malignancies Liang, Chaofeng Huang, Shuxin Zhao, Yujie Chen, Shaohua Li, Yangqiu Biomark Res Review TOX (thymocyte selection-associated HMG BOX) is a member of a family of transcriptional factors that contain the highly conserved high mobility group box (HMG-box) region. Increasing studies have shown that TOX is involved in maintaining tumors and promoting T cell exhaustion. In this review, we summarized the biological functions of TOX and its contribution as related to lymphocytic malignancies. We also discussed the potential role of TOX as an immune biomarker and target in immunotherapy for hematological malignancies. BioMed Central 2021-03-20 /pmc/articles/PMC7981945/ /pubmed/33743809 http://dx.doi.org/10.1186/s40364-021-00275-y Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liang, Chaofeng
Huang, Shuxin
Zhao, Yujie
Chen, Shaohua
Li, Yangqiu
TOX as a potential target for immunotherapy in lymphocytic malignancies
title TOX as a potential target for immunotherapy in lymphocytic malignancies
title_full TOX as a potential target for immunotherapy in lymphocytic malignancies
title_fullStr TOX as a potential target for immunotherapy in lymphocytic malignancies
title_full_unstemmed TOX as a potential target for immunotherapy in lymphocytic malignancies
title_short TOX as a potential target for immunotherapy in lymphocytic malignancies
title_sort tox as a potential target for immunotherapy in lymphocytic malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981945/
https://www.ncbi.nlm.nih.gov/pubmed/33743809
http://dx.doi.org/10.1186/s40364-021-00275-y
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AT huangshuxin toxasapotentialtargetforimmunotherapyinlymphocyticmalignancies
AT zhaoyujie toxasapotentialtargetforimmunotherapyinlymphocyticmalignancies
AT chenshaohua toxasapotentialtargetforimmunotherapyinlymphocyticmalignancies
AT liyangqiu toxasapotentialtargetforimmunotherapyinlymphocyticmalignancies

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