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The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli

BACKGROUND: Significant efforts have been made in building large-scale kinetic models of cellular metabolism in the past two decades. However, most kinetic models published to date, remain focused around central carbon pathways or are built around ad hoc reduced models without clear justification on...

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Detalles Bibliográficos
Autores principales: Hameri, Tuure, Fengos, Georgios, Hatzimanikatis, Vassily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981984/
https://www.ncbi.nlm.nih.gov/pubmed/33743594
http://dx.doi.org/10.1186/s12859-021-04066-y