Inhibition of EZH2 by chidamide exerts antileukemia activity and increases chemosensitivity through Smo/Gli-1 pathway in acute myeloid leukemia

BACKGROUND: Epigenetic dysregulation plays important roles in leukemogenesis and the progression of acute myeloid leukemia (AML). Histone acetyltransferases (HATs) and histone deacetylases (HDACs) reciprocally regulate the acetylation and deacetylation of nuclear histones. Aberrant activation of HDA...

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Detalles Bibliográficos
Autores principales: Jiang, Xuejie, Jiang, Ling, Cheng, Jiaying, Chen, Fang, Ni, Jinle, Yin, Changxin, Wang, Qiang, Wang, Zhixiang, Fang, Dan, Yi, Zhengshan, Yu, Guopan, Zhong, Qingxiu, Carter, Bing Z., Meng, Fanyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981995/
https://www.ncbi.nlm.nih.gov/pubmed/33743723
http://dx.doi.org/10.1186/s12967-021-02789-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981995/
https://www.ncbi.nlm.nih.gov/pubmed/33743723
http://dx.doi.org/10.1186/s12967-021-02789-3

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