In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure

New heart failure therapies that safely augment cardiac contractility and output are needed. Previous apelin peptide studies have highlighted the potential for APJ (apelin receptor) agonism to enhance cardiac function in heart failure. However, apelin’s short half-life limits its therapeutic utility...

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Detalles Bibliográficos
Autores principales: Gargalovic, Peter, Wong, Pancras, Onorato, Joelle, Finlay, Heather, Wang, Tao, Yan, Mujing, Crain, Earl, St-Onge, Stéphane, Héroux, Madeleine, Bouvier, Michel, Xu, Carrie, Chen, Xue-Qing, Generaux, Claudia, Lawrence, Michael, Wexler, Ruth, Gordon, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982131/
https://www.ncbi.nlm.nih.gov/pubmed/33663236
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.120.007351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982131/
https://www.ncbi.nlm.nih.gov/pubmed/33663236
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.120.007351

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