Cargando…

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure

New heart failure therapies that safely augment cardiac contractility and output are needed. Previous apelin peptide studies have highlighted the potential for APJ (apelin receptor) agonism to enhance cardiac function in heart failure. However, apelin’s short half-life limits its therapeutic utility...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gargalovic, Peter, Wong, Pancras, Onorato, Joelle, Finlay, Heather, Wang, Tao, Yan, Mujing, Crain, Earl, St-Onge, Stéphane, Héroux, Madeleine, Bouvier, Michel, Xu, Carrie, Chen, Xue-Qing, Generaux, Claudia, Lawrence, Michael, Wexler, Ruth, Gordon, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982131/ https://www.ncbi.nlm.nih.gov/pubmed/33663236 http://dx.doi.org/10.1161/CIRCHEARTFAILURE.120.007351

Ejemplares similares

The Apelin/APJ System in Psychosis and Neuropathy
por: Lv, Shuang-Yu, et al.
Publicado: (2020)

The Apelin-APJ System in the Evolution of Heart Failure
por: GOIDESCU, CERASELA MIHAELA, et al.
Publicado: (2015)

Expanding role for the apelin/APJ system in physiopathology
por: Carpéné, C., et al.
Publicado: (2007)

The Role of Apelin–APJ System in Diabetes and Obesity
por: Li, Cheng, et al.
Publicado: (2022)

The Role of the Apelin/APJ System in the Regulation of Liver Disease
por: Lv, Xinrui, et al.
Publicado: (2017)

Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction
por: Li, Bin, et al.
Publicado: (2021)

Apelin/APJ system: an emerging therapeutic target for neurological diseases
por: Li, Ao, et al.
Publicado: (2022)

Apelin/APJ system: A key therapeutic target for liver disease
por: Lv, Shuang-Yu, et al.
Publicado: (2017)

The Role of Apelin/APJ in a Mouse Model of Oxygen-induced Retinopathy
por: Feng, Jing, et al.
Publicado: (2020)

Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system
por: Liu, Wei, et al.
Publicado: (2020)

Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer
por: Liu, Longfei, et al.
Publicado: (2021)

Effect of L-Carnitine Supplementation on Apelin and Apelin Receptor (Apj) Expression in Cardiac Muscle of Obese Diabetic Rats
por: Ranjbar Kohan, Neda, et al.
Publicado: (2018)

Apelin-APJ Signaling: a Potential Therapeutic Target for Pulmonary Arterial Hypertension
por: Kim, Jongmin
Publicado: (2014)

Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression
por: Atluri, Pavan, et al.
Publicado: (2006)

Apelin, APJ, and ELABELA: Role in Placental Function, Pregnancy, and Foetal Development—An Overview
por: Dawid, Monika, et al.
Publicado: (2021)

THE EXPRESSION OF APELIN AND ITS RECEPTOR APJ DURING DIFFERENT PHYSIOLOGICAL STAGES IN THE BOVINE OVARY
por: Schilffarth, Stefanie, et al.
Publicado: (2009)

Apelin Receptor (APJ) Expression during Cardiopulmonary Bypass in Children Undergoing Surgical Repair
por: Walker, Susan, et al.
Publicado: (2014)

Fucoxanthin alters the apelin-13/APJ pathway in certain organs of γ-irradiated mice
por: El Bakary, Nermeen M, et al.
Publicado: (2021)

The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies
por: Li, Jiabin, et al.
Publicado: (2022)

Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats
por: Mehri, Keyvan, et al.
Publicado: (2019)

Retraction: Apelin Receptor (APJ) Expression during Cardiopulmonary Bypass in Children Undergoing Surgical Repair
Publicado: (2018)

Xiaoyaosan Improves Depressive-Like Behaviors in Mice through Regulating Apelin-APJ System in Hypothalamus
por: Yan, Zhiyi, et al.
Publicado: (2018)

Apelin13/APJ promotes proliferation of colon carcinoma by activating Notch3 signaling pathway
por: Chen, Tong, et al.
Publicado: (2017)

The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
por: Tian, Yanjun, et al.
Publicado: (2020)

The Apelin Receptor APJ in Hematopoietic Stem Cells/Progenitor Cells in the Early Stage of Non-Alcoholic Steatohepatitis
por: Ando, Wataru, et al.
Publicado: (2017)

Effect of the spinal apelin-APJ system on the pathogenesis of chronic constriction injury-induced neuropathic pain in rats
por: Xiong, Qingming, et al.
Publicado: (2017)

Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model
por: Yamazaki, Sahori, et al.
Publicado: (2020)

The Apelinergic System: Apelin, ELABELA, and APJ Action on Cell Apoptosis: Anti-Apoptotic or Pro-Apoptotic Effect?
por: Respekta, Natalia, et al.
Publicado: (2022)

Apelin Ameliorates TNF-α-Induced Reduction of Glycogen Synthesis in the Hepatocytes through G Protein-Coupled Receptor APJ
por: Chu, Jiaojiao, et al.
Publicado: (2013)

Interactive Association of Five Candidate Polymorphisms in Apelin/APJ Pathway with Coronary Artery Disease among Chinese Hypertensive Patients
por: Jin, Wei, et al.
Publicado: (2012)

Design and preclinical evaluation of a novel apelin-based PET radiotracer targeting APJ receptor for molecular imaging of angiogenesis
por: Louis, Béatrice, et al.
Publicado: (2023)

Correction: Apelin Ameliorates TNF-α-Induced Reduction of Glycogen Synthesis in the Hepatocytes through G Protein-Coupled Receptor APJ
por: Chu, Jiaojiao, et al.
Publicado: (2013)

Apelin/APJ axis improves angiotensin II-induced endothelial cell senescence through AMPK/SIRT1 signaling pathway
por: Yang, Rongfeng, et al.
Publicado: (2017)

Comparing High-Intensity Interval Training (HIIT) and Continuous Training on Apelin, APJ, NO, and Cardiotrophin-1 in Cardiac Tissue of Diabetic Rats
por: Sabouri, Mostafa, et al.
Publicado: (2020)

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension
por: Yang, Peiran, et al.
Publicado: (2017)

Effects of Dietary Eicosapentaenoic Acid (EPA) Supplementation in High-Fat Fed Mice on Lipid Metabolism and Apelin/APJ System in Skeletal Muscle
por: Bertrand, Chantal, et al.
Publicado: (2013)

Association study of apelin-APJ system genetic polymorphisms with incident metabolic syndrome in a Chinese population: a case-control study
por: Zhang, Meijin, et al.
Publicado: (2019)

Dapagliflozin: BMS 512148; BMS-512148
Publicado: (2012)

Hypoxia preconditioning promotes cardiac stem cell survival and cardiogenic differentiation in vitro involving activation of the HIF-1α/apelin/APJ axis
por: Hou, Jingying, et al.
Publicado: (2017)

Calibration and validation of the rabbit model of electrolytic‐mediated arterial thrombosis against the standard‐of‐care anticoagulant apixaban
por: Wong, Pancras C., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cv17l4vihpn8gq9rh51gv8bqfa