Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors

Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy. In this study, we synthesized and evaluated the biological activity of 66 pyrazolo[3,4-d]pyridazinone derivatives. Kinase inhibition, cell proliferation, and whole blood stability assays were used to...

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Detalles Bibliográficos
Autores principales: Wu, Xiaowei, Dai, Mengdi, Cui, Rongrong, Wang, Yulan, Li, Chunpu, Peng, Xia, Zhao, Jihui, Wang, Bao, Dai, Yang, Feng, Dan, Yang, Tianbiao, Jiang, Hualiang, Geng, Meiyu, Ai, Jing, Zheng, Mingyue, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982429/
https://www.ncbi.nlm.nih.gov/pubmed/33777682
http://dx.doi.org/10.1016/j.apsb.2020.09.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982429/
https://www.ncbi.nlm.nih.gov/pubmed/33777682
http://dx.doi.org/10.1016/j.apsb.2020.09.002

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