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Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy. In this study, we synthesized and evaluated the biological activity of 66 pyrazolo[3,4-d]pyridazinone derivatives. Kinase inhibition, cell proliferation, and whole blood stability assays were used to...
Autores principales: | Wu, Xiaowei, Dai, Mengdi, Cui, Rongrong, Wang, Yulan, Li, Chunpu, Peng, Xia, Zhao, Jihui, Wang, Bao, Dai, Yang, Feng, Dan, Yang, Tianbiao, Jiang, Hualiang, Geng, Meiyu, Ai, Jing, Zheng, Mingyue, Liu, Hong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982429/ https://www.ncbi.nlm.nih.gov/pubmed/33777682 http://dx.doi.org/10.1016/j.apsb.2020.09.002 |
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