The Emerging Role of Neuropeptides in Parkinson’s Disease
Parkinson’s disease (PD), the second most common age-related neurodegenerative disease, results from the loss of dopamine neurons in the substantia nigra. This disease is characterized by cardinal non-motor and motor symptoms. Several studies have demonstrated that neuropeptides, such as ghrelin, ne...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982480/ https://www.ncbi.nlm.nih.gov/pubmed/33762925 http://dx.doi.org/10.3389/fnagi.2021.646726 |
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author | Zheng, Yanan Zhang, Linlin Xie, Junxia Shi, Limin |
author_facet | Zheng, Yanan Zhang, Linlin Xie, Junxia Shi, Limin |
author_sort | Zheng, Yanan |
collection | PubMed |
description | Parkinson’s disease (PD), the second most common age-related neurodegenerative disease, results from the loss of dopamine neurons in the substantia nigra. This disease is characterized by cardinal non-motor and motor symptoms. Several studies have demonstrated that neuropeptides, such as ghrelin, neuropeptide Y, pituitary adenylate cyclase-activating polypeptide, substance P, and neurotensin, are related to the onset of PD. This review mainly describes the changes in these neuropeptides and their receptors in the substantia nigra-striatum system as well as the other PD-related brain regions. Based on several in vitro and in vivo studies, most neuropeptides play a significant neuroprotective role in PD by preventing caspase-3 activation, decreasing mitochondrial-related oxidative stress, increasing mitochondrial biogenesis, inhibiting microglial activation, and anti-autophagic activity. Thus, neuropeptides may provide a new strategy for PD therapy. |
format | Online Article Text |
id | pubmed-7982480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79824802021-03-23 The Emerging Role of Neuropeptides in Parkinson’s Disease Zheng, Yanan Zhang, Linlin Xie, Junxia Shi, Limin Front Aging Neurosci Neuroscience Parkinson’s disease (PD), the second most common age-related neurodegenerative disease, results from the loss of dopamine neurons in the substantia nigra. This disease is characterized by cardinal non-motor and motor symptoms. Several studies have demonstrated that neuropeptides, such as ghrelin, neuropeptide Y, pituitary adenylate cyclase-activating polypeptide, substance P, and neurotensin, are related to the onset of PD. This review mainly describes the changes in these neuropeptides and their receptors in the substantia nigra-striatum system as well as the other PD-related brain regions. Based on several in vitro and in vivo studies, most neuropeptides play a significant neuroprotective role in PD by preventing caspase-3 activation, decreasing mitochondrial-related oxidative stress, increasing mitochondrial biogenesis, inhibiting microglial activation, and anti-autophagic activity. Thus, neuropeptides may provide a new strategy for PD therapy. Frontiers Media S.A. 2021-03-08 /pmc/articles/PMC7982480/ /pubmed/33762925 http://dx.doi.org/10.3389/fnagi.2021.646726 Text en Copyright © 2021 Zheng, Zhang, Xie and Shi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zheng, Yanan Zhang, Linlin Xie, Junxia Shi, Limin The Emerging Role of Neuropeptides in Parkinson’s Disease |
title | The Emerging Role of Neuropeptides in Parkinson’s Disease |
title_full | The Emerging Role of Neuropeptides in Parkinson’s Disease |
title_fullStr | The Emerging Role of Neuropeptides in Parkinson’s Disease |
title_full_unstemmed | The Emerging Role of Neuropeptides in Parkinson’s Disease |
title_short | The Emerging Role of Neuropeptides in Parkinson’s Disease |
title_sort | emerging role of neuropeptides in parkinson’s disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982480/ https://www.ncbi.nlm.nih.gov/pubmed/33762925 http://dx.doi.org/10.3389/fnagi.2021.646726 |
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