A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors

The protein tyrosine phosphatase Src homology phosphotyrosyl phosphatase 2 (SHP2) is implicated in various cancers, and targeting SHP2 has become a promising therapeutic approach. We herein described a robust cross-validation high-throughput screening protocol that combined the fluorescence-based en...

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Detalles Bibliográficos
Autores principales: Song, Yihui, Zhao, Min, Wu, Yahong, Yu, Bin, Liu, Hong-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982506/
https://www.ncbi.nlm.nih.gov/pubmed/33777680
http://dx.doi.org/10.1016/j.apsb.2020.10.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982506/
https://www.ncbi.nlm.nih.gov/pubmed/33777680
http://dx.doi.org/10.1016/j.apsb.2020.10.021

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