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Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation

Type 1 diabetes (T1D) is a disorder of impaired glucoregulation due to lymphocyte-driven pancreatic autoimmunity. Mobilizing dendritic cells (DC) in vivo to acquire tolerogenic activity is an attractive therapeutic approach as it results in multiple and overlapping immunosuppressive mechanisms. Deli...

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Detalles Bibliográficos
Autores principales:	Phillips, Brett E., Garciafigueroa, Yesica, Engman, Carl, Liu, Wen, Wang, Yiwei, Lakomy, Robert J., Meng, Wilson S., Trucco, Massimo, Giannoukakis, Nick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982719/ https://www.ncbi.nlm.nih.gov/pubmed/33763059 http://dx.doi.org/10.3389/fimmu.2021.586220

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