Interplay Between Sialic Acids, Siglec-E, and Neu1 Regulates MyD88- and TRIF-Dependent Pathways for TLR4-Activation During Leishmania donovani Infection

TLR4 activates two distinct signaling pathways involving adaptors MyD88 and TRIF to produce proinflammatory cytokines and type-I interferon respectively. How Leishmania donovani suppresses these pathways is not well studied. We earlier reported, TLR4 is hypersialylated due to reduced membrane-bound...

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Detalles Bibliográficos
Autores principales: Karmakar, Joyshree, Mandal, Chitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982817/
https://www.ncbi.nlm.nih.gov/pubmed/33763070
http://dx.doi.org/10.3389/fimmu.2021.626110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982817/
https://www.ncbi.nlm.nih.gov/pubmed/33763070
http://dx.doi.org/10.3389/fimmu.2021.626110

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