Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice

Sickle cell disease (SCD) is an inherited hemolytic disorder, defined by a point mutation in the β-globin gene. Stress conditions such as infection, inflammation, dehydration, and hypoxia trigger erythrocyte sickling. Sickled red blood cells (RBCs) hemolyze more rapidly, show impaired deformability,...

Descripción completa

Detalles Bibliográficos
Autores principales: Yalamanoglu, Ayla, Dubach, Irina L., Schulthess, Nadja, Ingoglia, Giada, Swindle, Delaney C., Humar, Rok, Schaer, Dominik J., Buehler, Paul W., Irwin, David C., Vallelian, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982888/
https://www.ncbi.nlm.nih.gov/pubmed/33763072
http://dx.doi.org/10.3389/fimmu.2021.627944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982888/
https://www.ncbi.nlm.nih.gov/pubmed/33763072
http://dx.doi.org/10.3389/fimmu.2021.627944

Ejemplares similares